Molecular hydrogen alleviates asthma through inhibiting the "biological triggers"and ongoing gene expression as long as two weeks thereafter.

WHAT IS ASTHMA?

Asthma is one of the most common noninfectious chronic diseases characterized by type II inflammation triggered by various environmental and stress conditions.

Various studies ( Both Clinical and Laboratory) have confirmed that the inhalation Hydrogen is very efficient at the triggers that lead to asthma attacks, by inhibiting and down regulating BALF levels of IL-33 and other alarmin and type II cytokines and suppressing the expression of NF-?B and ST2.

• Bronchoalveolar lavage fluid (BALF), which is commonly gathered during the diagnostic workup of pulmonary sarcoidosis, is thought to contain the immune cells found in lung alveoli and can therefore provide important information regarding the immunological response that takes place.
•  IL-33 is an alarming marker that is released when cell damage occurs due to allergic inflammation in various allergic diseases,like asthma
• .NF-?B plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells.
• ST2 is a member of the interleukin 1 receptor family. The ST2 protein has two isoforms and is directly implicated in the progression of cardiac disease:

Hydrogen further inhibited and significantly reduces, ILC2, E-cadherin and ZO-1 levels. Following various longer term clinical studies on the effect of inhalation of Hydrogen on lung structure injury as a result of chronic inflammation (https://kyksa.com/molecular-hydrogen-and-covid-19) and the remedial affects on the fibrotic and inflamed tissue it is fair to conclude that the continuous use / inhalation of hydrogen gas could lead to longer term remedial affects of these symptoms brought about by Asthma. More and longer term research is also needed to quantify this deduction in real long term human studies.

Unregulated  an aggressive inflammatory response with the release of a large amount of pro-inflammatory cytokines in an event known as ?cytokine storm.? causing an acute inflammatory response

Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells. Many of these cells recognize the non-polymorphic CD1d molecule

Conclusions

An ever growing volume of clinical / laboratory and anecdotal studies are proving that Hydrogen gas inhalation / ingestion, is both a very strong antioxidant and potent anti-inflammatory agent and is efficient in suppressing allergen-induced asthma and could be developed as a therapeutics for asthma and other conditions of type II inflammation.